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Thymosin Alpha-1 10mg | Gut Health & Inflammation Research Peptide

Q: What is Thymosin Alpha-1 used for in research?

Thymosin Alpha-1 (Tα1) is a naturally occurring 28-amino acid peptide derived from prothymosin alpha, produced by the thymus gland. In research settings it is studied for its immunomodulatory properties, particularly its role in regulating inflammatory cytokine cascades, supporting gut mucosal barrier integrity, and modulating T-cell activity. Research protocols typically examine its influence on systemic inflammatory markers, gut biome signalling, and internal skin integrity support.

Q: How do you reconstitute Thymosin Alpha-1 10mg powder?

For research use, Thymosin Alpha-1 lyophilized powder is typically reconstituted with bacteriostatic water or sterile water. A common approach is to add 1–2ml of solvent per 10mg vial, introducing the liquid slowly down the inner wall without direct injection onto the powder. Gently swirl until fully dissolved — do not shake or vortex. Store the reconstituted solution refrigerated at 2–8°C, protected from light, and avoid freeze-thaw cycles.

Thymosin Alpha-1 (Tα1) is lyophilized synthetic peptide used as a tool compound for research into gut health regulation, systemic inflammation pathways, and the biological support of skin integrity from an internal perspective.

Original price was: $120.00.Current price is: $100.00.

Suggested protocol

Timing: Night
Cycle: 6-8 weeks ON / 4 week OFF
Goal: Gut health, inflammation & skin support

High
Purity

CoA
Available

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Thymosin Alpha-1 (Tα1) is a naturally occurring 28 amino acid peptide derived from prothymosin alpha, produced endogenously by the thymus gland. It is utilized in laboratory studies focused on gut health regulation, systemic inflammation pathways and the biological support of skin integrity from an internal perspective. As an immunomodulatory tool compound, Tα1 is studied for its ability to regulate inflammatory cytokine cascades and support gut mucosal barrier integrity. BPeptide’s Thymosin Alpha-1 10mg is supplied as a lyophilized powder, verified for identity and purity by independent third party analysis.

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Gut Health Regulation Research

Used to investigate gut mucosal barrier integrity and gut biome signalling pathways, examining how Tα1 influences intestinal lining homeostasis in controlled laboratory settings.

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Systemic Inflammation Pathways

Studied for its immunomodulatory capacity to regulate pro-inflammatory cytokine cascades, including TNF-α, IL-6, and IL-1β, across defined research cycles.

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Internal Skin Integrity Support

Research explores Tα1’s role in supporting skin integrity from an internal biological perspective, linked to its modulation of inflammatory and immune signalling networks.

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Stable Lyophilized Format

Supplied as lyophilized powder for extended shelf stability, supporting reproducible assay conditions across longitudinal 6-8 week research protocols.

Product Name

Thymosin Alpha-1 (Tα1)

Also Known As

Thymalfasin, Zadaxin

CAS Number

62304-98-7

Sequence

Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH

Amino Acids

28 amino acids

Molecular Formula

C₁₂₉H₂₁₅N₃₃O₅₅

Molecular Weight

~3108.3 g/mol

Quantity

10mg lyophilized powder

SKU

THY10

Appearance

White to off white lyophilized powder

Solubility

Water soluble at research relevant concentrations

Storage (lyophilized)

2–8°C (36–46°F), cool and dark, protected from moisture and light

Certificate of Analysis

Available on request

Category

Recovery & Gut Health

Intended Use

In vitro / laboratory research only

Standard Reconstitution Protocol

Allow the vial to reach room temperature before opening.
Wipe the rubber stopper with 70% isopropyl alcohol.
Using a sterile syringe, add 1.0-2.0ml of bacteriostatic or sterile water slowly down the inner wall of the vial so do not inject directly onto the powder.
Gently swirl until fully dissolved. Do not shake or vortex because this can denature the molecule.
Label the vial with date of reconstitution.
Store refrigerated, protected from light and avoid repeated freeze thaw cycles. Do not freeze reconstituted solution.

Reconstitution solvent	Bacteriostatic water (preferred) or sterile water
Recommended volume	1.0-2.0ml per 10mg vial
Storage after reconstitution	2–8°C (36–46°F), in dark, upright
Freeze-thaw cycles	Avoid; do not freeze reconstituted solution
Suggested cycle	6–8 weeks ON / 4 week OFF
Timing	Night time laboratory sessions
Maintenance cycle	Repeat periodically for longitudinal gut biome and inflammatory marker tracking

What is Thymosin Alpha-1 used for in research?

Thymosin Alpha-1 (Tα1) is a naturally occurring 28 amino acid peptide derived from prothymosin alpha, produced by the thymus gland. In research settings it is studied for its immunomodulatory properties, particularly its role in regulating inflammatory cytokine cascades, supporting gut mucosal barrier integrity, and modulating T-cell activity. Research protocols typically examine its influence on systemic inflammatory markers, gut biome signalling and internal skin integrity support.

How do you reconstitute Thymosin Alpha-1 10mg powder?

Thymosin Alpha-1 lyophilized powder is typically reconstituted with bacteriostatic water or sterile water. Add 1-2ml of solvent per 10mg vial, introducing the liquid slowly down the inner wall without direct injection onto the powder. Gently swirl until dissolved so do not shake or vortex. Store the reconstituted solution refrigerated at 2-8°C, protected from light and avoid freeze thaw cycles. Full protocol is in the Reconstitution tab above.

What is the purity of this Thymosin Alpha-1 peptide?

Our Thymosin Alpha-1 10mg is manufactured to high purity, verified by independent third party HPLC analysis. A certificate of analysis (CoA) is available on request before or after purchase.

How should Thymosin Alpha-1 powder be stored?

Store lyophilized Thymosin Alpha-1 powder at 2–8°C (36–46°F) in a cool, dark environment, protected from moisture and light to prevent degradation. Once reconstituted, keep the solution refrigerated and avoid repeated freeze thaw cycles. Do not freeze the reconstituted solution.

What is the suggested research protocol timing for Thymosin Alpha-1?

The standard research protocol for Thymosin Alpha-1 uses night time laboratory sessions for administration, with a cycle of 6-8 weeks ON followed by a mandatory 4 week OFF period for baseline observation. Maintenance cycles may be repeated periodically for ongoing monitoring of gut biome and inflammatory response markers.

Do you ship internationally?

Yes, we ship worldwide. Free shipping is included on qualifying orders. Cold chain packaging is used for all peptide orders to help maintain product integrity during transit.

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What is Thymosin Alpha-1 and How Does It Relate to Gut Health & Inflammation Research?

Thymosin Alpha-1 (Tα1) is a naturally occurring 28 amino acid peptide first isolated from thymosin fraction 5 of bovine thymus tissue. It is derived from the N-terminal region of prothymosin alpha and is endogenously produced in the thymus gland. Its molecular formula is C₁₂₉H₂₁₅N₃₃O₅₅ with a molecular weight of approximately 3108.3 g/mol, and it carries the CAS number 62304-98-7.

The gut health and inflammation research application of Thymosin Alpha-1 is rooted in its documented immunomodulatory activity. Tα1 has been studied extensively for its ability to modulate T-cell responses, regulate pro inflammatory cytokine production (including TNF-α, IL-6, and IL-1β) and enhance dendritic cell maturation. In gut health research, Tα1 is examined for its potential role in supporting mucosal barrier function and modulating the gut immune axis, an area of active investigation in inflammatory bowel and systemic inflammation research models.

Researchers employing Thymosin Alpha-1 typically design protocols around a 6-8 week ON cycle with a 4 week OFF baseline period, conducted during night time laboratory sessions. This structured approach enables clear measurement windows for inflammatory response markers, gut biome parameters and skin integrity indicators.