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TB-500 10mg | Metabolic Regulatory & Insulin Sensitivity Research Peptide
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TB-500 10mg | Metabolic Regulatory & Insulin Sensitivity Research Peptide

Thymosin Beta-4 (TB-500) is lyophilized synthetic peptide used as a tool compound for research into metabolic regulation pathways and insulin sensitivity markers.

Original price was: $120.00.Current price is: $100.00.

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Suggested protocol
  • Timing: Morning
  • Cycle: 2-4 weeks ON / 4 week OFF
  • Goal: Metabolism, insulin sensitivity

High
Purity

CoA
Available

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Shipping

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Ordering

TB-500 is a synthetic analog of Thymosin Beta-4, a naturally occurring 43 amino acid peptide ubiquitously expressed in mammalian cells and known for its role in actin sequestration and cellular signaling. As a tool compound, TB-500 is used in laboratory investigations into metabolic regulatory pathways and insulin sensitivity, examining how Thymosin Beta-4-related signaling may influence energy expenditure, glucose metabolism, and metabolic optimization at a cellular level. BPeptide’s TB-500 10mg is supplied as a lyophilized powder, verified for identity and purity by independent third party analysis.

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Metabolic Regulation Research

Used to investigate cellular signaling pathways related to energy expenditure and metabolic optimization in controlled laboratory settings.

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Insulin Sensitivity Tracking

Studied for its potential role in modulating insulin response markers and glucose metabolism signaling across defined research cycles.

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Actin-Binding Peptide Scaffold

Thymosin Beta-4’s documented role in actin sequestration provides a well characterized molecular scaffold for downstream signaling studies.

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Stable Lyophilized Format

Supplied as lyophilized powder for extended shelf stability, supporting reproducible assay conditions across longitudinal research protocols.

Product Name
TB-500 (Thymosin Beta-4 Synthetic Analog)
CAS Number
77591-33-4
Sequence
Ac-LKKTETQ (N-terminal fragment Ac-SDKPDMAEIEKFDKSKLKKTEDQD…)
Molecular Formula
C₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight
~4963.5 g/mol
Quantity
10mg lyophilized powder
SKU
TB-500-10
Appearance
White to off white lyophilized powder
Solubility
Water soluble at research-relevant concentrations
Storage (lyophilized)
2–8°C (36–46°F), cool and dark, protected from moisture and light
Certificate of Analysis
Available on request
Category
Metabolism & Weight
Intended Use
In vitro / laboratory research only

Standard Reconstitution Protocol

  1. Allow the vial to reach room temperature before opening.
  2. Wipe the rubber stopper with 70% isopropyl alcohol.
  3. Using a sterile syringe, add 1.0–2.0ml of bacteriostatic or sterile water slowly down the inner wall of the vial so do not inject directly onto the powder.
  4. Gently swirl until fully dissolved. Do not shake or vortex because this can denature the molecule.
  5. Label the vial with date of reconstitution.
  6. Store refrigerated, protected from light and avoid repeated freeze thaw cycles. Do not freeze reconstituted solution.
Reconstitution solvent Bacteriostatic water (preferred) or sterile water
Recommended volume 1.0-2.0ml per 10mg vial
Storage after reconstitution 2-8°C (36–46°F), in dark, upright
Freeze-thaw cycles Avoid; do not freeze reconstituted solution
Suggested cycle 2-4 weeks ON, 4 week OFF
Maintenance cycle Repeat periodically for longitudinal insulin response and metabolic efficiency tracking

What is TB-500 used for in research?

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TB-500 is a synthetic analog of Thymosin Beta-4, a naturally occurring 43-amino acid peptide that plays a role in actin sequestration and cellular signaling. In this listing it is used for research into metabolic regulation pathways and insulin sensitivity markers, examining how TB-500-related signaling may influence energy expenditure, glucose metabolism and metabolic optimization at a cellular level.

How do you reconstitute TB-500 10mg powder?

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For research use, TB-500 lyophilized powder is typically reconstituted with bacteriostatic water or sterile water. Add 1-2ml of solvent per 10mg vial, introducing the liquid slowly down the inner wall without direct injection onto the powder. Gently swirl until dissolved so do not shake or vortex. Store the reconstituted solution refrigerated at 2-8°C, protected from light, and avoid freeze thaw cycles. Full protocol is in the Reconstitution tab above.

What is the purity of this TB-500 peptide?

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Our TB-500 10mg is manufactured to high purity, verified by independent third party HPLC analysis. A certificate of analysis (CoA) is available on request before or after purchase.

How should TB-500 powder be stored?

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Store lyophilized TB-500 powder at 2-8°C (36–46°F) in a cool, dark environment, protected from moisture and light to prevent degradation. Once reconstituted, keep the solution refrigerated and avoid repeated freeze thaw cycles. Do not freeze the reconstituted solution.

What is the suggested research protocol timing for TB-500?

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The standard research protocol for TB-500 uses morning laboratory sessions for administration, with a cycle of 2-4 weeks ON followed by a mandatory 4 week OFF period for baseline observation. Maintenance cycles of 2-4 weeks ON followed by 4 weeks OFF may be utilized for ongoing monitoring of insulin response stability and metabolic efficiency.

Do you ship internationally?

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Yes, we ship worldwide. Free shipping is included on qualifying orders. Cold-chain packaging is used for all peptide orders to help maintain product integrity during transit.

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What is TB-500 and How Does It Relate to Metabolic Regulation Research?

TB-500 (Thymosin Beta-4) is a synthetic analog of a naturally occurring 43 amino acid peptide found in virtually all nucleated mammalian cells. Thymosin Beta-4 is best characterized in the scientific literature for its role in sequestering G-actin monomers, thereby regulating actin dynamics, cytoskeletal organization, and a broad range of downstream cellular processes. Its molecular formula is C₂₁₂H₃₅₀N₅₆O₇₈S with a molecular weight of approximately 4963.5 g/mol, and it carries the CAS number 77591-33-4.

The metabolic research application of TB-500 centers on its downstream signaling interactions. Thymosin Beta-4 peptides have been examined for their potential involvement in cellular energy homeostasis, with preliminary research interest in how Tβ4 related pathways may intersect with insulin sensitivity markers and metabolic efficiency. Researchers employing this compound typically design protocols around defined ON/OFF cycling commonly 2-4 weeks ON with a 4 week recovery period to create clear baseline windows for measuring changes in glucose regulation and metabolic response parameters.

Because TB-500 functions as a well-characterized actin regulatory peptide, it serves as a reproducible tool compound for laboratories exploring secondary questions about metabolic signaling. As with any peptide used outside its most extensively documented context, findings should be interpreted alongside the wider Thymosin Beta-4 pharmacology literature.

BPeptide supplies TB-500 10mg lyophilized powder for use in laboratory research applications. This product is sold strictly for research purposes and is not intended for human or veterinary use.

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